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Clinically, AMK poses significant safety constraints: it is absolutely contraindicated in pregnancy due to fetal ototoxicity (Pacifici and Marchini 2020) and exhibits hazardous interactions with nephrotoxic (cisplatin, loop diuretics) or incompatible (penicillins) drugs (Sales and Foresto 2020)

The use of more complex techniques as the one-path and the two-path impedance spectroscopy is able to measure the two components of the R epi , the R para and the R trans (R epi = R para + R trans ) on top of the R bas ( Importantly, TEER does not discriminate between the above-mentioned pore and leak pathways since an increased permeability of both pathways will reduce TEER

HIFs play a central role in adaptive regulation of energy metabolism under hypoxic conditions, facilitating the conversion from mitochondrial oxidative phosphorylation to glycolysis

Electrophoresis 22(13):28242831