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In developing countries, individuals with unrepaired clefts cannot eat or speak properly, are kept from attending school or obtaining employment and may be subjected to further abuse and cruelty as a result of their birth defect

[3] Overdose and toxicity [edit] Excessive amounts of valproic acid can result in somnolence, tremor, stupor, respiratory depression, coma, metabolic acidosis, and death

Since L-dopa is converted to dopamine in the CNS and the peri phery, peripheral conversion and systemic effects can be reduced by combining L-dopa with carbi dopa (a peripheral decarboxylation inhibitor), which does not cross the bloodbrain barrier

doi: 10.3892/ijmm.2025.5519 89 ZhongYXiaoQHuangJYuSChenLWanQet al