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Intriguingly, significant correlation between NCOA4 expression levels in lung homogenates and a decline in FEV1/FVC was demonstrated, which may reflect clinical implications for NCOA4-mediated ferritinophagy in COPD

Life Sci 1999;65:PL309-16

Mastroberardino, P

[11] Lactic acid fermentation In animals, aside from a few exceptions, and in many microorganisms, when oxygen availability is insufficient to meet the cells energy demands, or when the cell lacks mitochondria , the pyruvate generated by glycolysis is reduced to lactate in the cytosol