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Nasal delivery has higher bioavailability for some peptides, particularly neuropeptides like Semax and Selank, due to the nasal mucosa direct proximity to the brain and rich vascularization

N.KodaliM.AttaluriS.ShuaiB.MelissariL.RaoX.et al

This indicates that REM sleep is necessary for the selective elimination of presumably unnecessary experience-associated spines, which allows to free up space in neuronal circuits

The overlap and complementarity of aerobic exercise and tDCS in pathways such as BDNF, dopamine, and glutamate provide a biological basis for their synergistic enhancement (Steinberg et al., 2019