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Science 333 , 13031307 (2011)

Moreover, both hypoxia (via HIF-1) and TGF signaling can independently stimulate the VEGF and CXCR4 expression to drive breast cancer bone metastases (107)

the peptide comprises a peptide comprising or consisting of 8 or more contiguous amino acids from the amino acid sequence of any one of SEQ ID NOs 1-75

Systemic effects do occur after local injections : measurable HPA-axis suppression commonly lasts 24 weeks (longer with higher doses/frequency), and short-term suppression of immune cell counts and cytokines is documented