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Front Biosci (2008) 13:532344

RF could destroy HepG2 cells by upregulating the expressions of pro-apoptotic proteins p53 and Bax, and downregulating levels of pro-caspase 3 and pro-caspase 9, as well as inhibiting the expression of antiapoptotic protein Bcl-2, therefore promoting release of caspase 3 and caspase 9 (Zhang Z

A sex-specific effect of HHcy is also reported, with elevated Hcy associated with greater motor impairment in male PD patients and poorer cognitive performance in female PD patients [157]