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However, in diabetes, oxidative stress and chronic inflammation alter IRP activity, leading to iron metabolism dysregulation, iron overload, and increased ferroptosis ( 2.3 Role of oxidative stress in diabetic cardiomyopathy In DCM, the disruption of iron homeostasis and persistent oxidative stress are key drivers of ferroptosis (62)

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Disrupted NMDA signaling has also been implicated in a wide range of neuropsychiatric disorders other than ASD, including ID, schizophrenia, Alzheimers disease, and other mood disorders [66], suggesting different roles of NMDARs in synaptic plasticity and excitotoxicity [67, 68]

10.1155/2022/5491038 Oxid Med Cell Longev