l-carnitine and time to exhaustion Carnitine Deficiency: What Is It, Causes, Symptoms, More Effect of Acute and Chronic

The reduced form GSH is the active form of the molecule, it is the most abundant and it is found inside the cells in millimolar concentrations in the range of 110 mM (highest concentration in liver) (8), while extracellularly they are found in micromolar (GSH in plasma: 1030 M) levels (15, 16)

doi: 10.1007/s00018-024-05489-5 86

doi: 10.1093/nar/gku1160 100 HoseiniZBehpourNHoseiniR

Recommended daily intake: Adults: 10-13mg per kg body weight per day For a 70kg (154lb) person: approximately 700-910mg methionine daily Athletes or those with higher needs: 15-20mg per kg body weight Sample daily meal plan to increase homocysteine: Breakfast: 2 eggs scrambled (380mg) 30g cheese (200mg) Total: ~580mg methionine Lunch: 150g chicken breast (1,400mg) Quinoa salad (95mg per 100g serving) Total: ~1,500mg methionine Snack: 30g Brazil nuts (300mg) Total: ~300mg methionine Dinner: 150g salmon (940mg) Roasted vegetables Total: ~940mg methionine Daily total: ~3,320mg methionine (well above minimum requirements) Vegan/vegetarian meal plan: Breakfast: Oatmeal with hemp seeds and Brazil nuts (500mg+) Fortified plant milk (varies) Lunch: Tofu stir-fry with quinoa (400mg+) Sesame seed garnish (100mg) Snack: Sunflower seed butter on whole grain bread (300mg) Dinner: Lentil and chickpea curry (200mg) Brown rice (60mg) Daily total: ~1,560mg methionine (adequate for most people, though lower than omnivorous diet) Important considerations: Balance is key: You want to raise homocysteine to optimal levels (6-9 mol/L), not create high homocysteine