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Four randomized clinical studies (RCT) demonstrated the superior efficacy of ALC over placebo (PBO) in patients with depression. Sung, DJ, et al, Role of l-carnitine in sports performance: Focus on ergogenic aid and antioxidant in Science & Sports , Volume 31, Issue 4, September 201, pp 177 - 188

In relation to chronic studies, increased VO 2peak (11, 16) and decreased respiratory quotients (12, 32) have been presented, while many groups have reported no differences (3, 5, 6, 10, 13, 18, 23, 30)