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We believe that codifying these removal factors will provide transparency and consistency with removals of improvement activities from the Inventory by requiring that elements of each activity are objectively reviewed and justification for removal is clearly identified

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For instance, up-regulated Tregs cells in the TME induce DNA damage in CD4(+) T and CD8(+) T cells and overexpress senescence-associated -galactosidase (SA--Gal), promoting cell cycle progression and growth arrest in the G0/G1 phase, leading to T cells senescence and impaired tumour immunosuppressive capacities, which are co-regulated by MAPK and STAT1/STAT3 signaling pathways (226)

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