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falciparum has some capacity to synthesize its own lipids (reviewed in ONeal et al., 2020), several classes of lipids are rate-limiting and must also be obtained from an extracellular source (ONeal et al., 2020)

If you fish around the internet enough, you will find some anecdotal claims of insomnia and restlessness linked to excessive B12 intake, but direct causality has yet to be analyzed by experts

Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis