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Quality may be more important than quantity

Towards this end, we defined the physiology of hepatocytes by integrating in the human Recon3D model publicly available fluxomics data for 92 boundary reactions 29 and metabolomics data for 213 metabolites 30 from previous hepatocyte model reconstructions

Moreover, the combination of novel drugs with existing treatment modalities (e.g., SGLT2 inhibitors with ferroptosis inhibitors, antioxidants like selenocysteine with Ferrostatin-1 or Liproxstatin-1, and GLP-1 receptor agonists with ferroptosis inhibitors) (207209) will be an important area of future research

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