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Further supporting this, Makishima et al., in a cholestasis model, demonstrated that TCDD pretreatment significantly enhanced the production of inflammatory cytokines such as TNF and IL-1B in the plasma of bile duct ligated (BDL) mice, indicating that AhR signaling can markedly worsen cholestasis-associated inflammatory responses ( It is noteworthy that AhR exhibits a significant context-dependent dual role in inflammatory regulation

Ann Plast Surg 84(2):208215

10.3945/an.114.007500 Adv

The bioavailability, purity, and chelation stability of the raw ingredient directly determine how much magnesium reaches the brain, and in what form