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Epigenetic mechanisms regulate the expression of genes crucial for immune response, neuronal function, and synaptic plasticity in neuroinflammatory processes

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In addition, Daratumumab reduces the types of inhibitory cells in the TME of multiple myeloma, i.e., it consumes immuno-suppressive cells such as CD38 + MDSCs, Tregs, and Bregs, and enhances anti-tumor activity ( + Treg depletion and induce the proliferation and functional recovery of effector T cells ( Figure 2 )