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The previous ligation mixture containing the bifunctional peptide intermediate was then diluted with the solution of TCEP (2.28 mL) and the mixture was stirred at 37 C for 40 h

That could explain, at least in part, why membrane discs are disorganized in mutant mice, participating to the OS collapse

The red-light-activated phytochromes directly interact with PIFs and trigger rapid phosphorylation, ubiquitination and degradation of PIFs to release photomorphogenic development

Current clinical practices in the general population, including in patients with diabetes, focus on reducing disease-promoting risk factors, such as hyperglycaemia, hyperlipidaemia and hypertension, but do not target the diabetes-induced mechanisms of atherosclerosis development and progression