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J Neurochem 116:508521 Pullens B, van Benthem PP (2011) Intratympanic gentamicin for menieres disease or syndrome

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As mentioned earlier, under physiological conditions, the body maintains a low serum-free Cu concentration through various proteins such as ATP7A/ATP7B, SLC31A1/CTR1, and Cu chaperone antioxidant protein 1 (ATOX1), thereby reducing the Fenton reaction, oxidative stress, and non-target tissue accumulation mediated by it ( 2+ overload, cancer cells activate the Wnt/-catenin signaling pathway, promote the binding of the -catenin/TCF4 complex to ATP7B, leading to upregulated ATP7B expression, increased Cu efflux, and decreased cytoplasmic Cu concentration, thereby enabling tumor cells to escape the cuproptosis process (Liu et al., 2024)

Liguori et al., 2018) (Figure 1)