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A number of studies from recent years have shown repeatedly that melatonin reduces dramatically the expression of collagen, and thus, glial scar formation in an injured nerve, thereby enabling the successful neurite regrowth and consecutive muscular reinnervation (Turgut et al., 2005

On the other hand, mitochondrial fragmentation also leads to excessive accumulation of reactive oxygen species (ROS), further damaging T-cell DNA and proteins, exacerbating cellular functional decline (146)