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Men with underlying cardiovascular issues must approach this therapy cautiously, and all users should be aware of the dos and donts (no more than one dose per 24 hours, etc.) to use it safely.When used correctly, the safety data is reassuring: side effects are generally transient and manageable, with transient blood pressure increasesbeing the main concern to monitorfda.gov

Figure 2 highlights the diverse health advantages of polyphenols: a visual depiction of their functions in enhancing antioxidant capacity, mitigating alcohol-related hepatic damage, obstructing carcinogenic effects, retarding the aging process, regulating gut microbiota, facilitating weight management and obesity prevention, reducing blood glucose levels, augmenting nutritional value, and substituting preservatives by inhibiting pathogenic bacterial proliferation

All research cited on this page is from preclinical animal studies

However, the clinical significance of this is unclear (144)