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Oral administration creates slower absorption with sustained but lower peak concentrations due to first-pass metabolism, which may reduce the need for daily dosing as the compound remains bioavailable for extended periods

Although several studies in cortex reported changes in spine density, more recent studies have reported no significant spine density changes in fmr1 knockout mice (Cruz-Martn et al., 2010

Purpose-formulated topical preparations or sterile application techniques would be preferable to potentially introducing contaminants to open wounds

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