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Using immunoblotting, components of U1-snRNP (U1-70K, U1-A, U1-C and sm-B/D), SMN (Gemin 5 and SMN) and polyadenylation (CPSF-160 and PABP) were confirmed to be selectively present in the FUS/TLS affinity purified fraction of the LAP-tagged FUS/TLS-expressing cell extracts (Fig

Additionally, the downregulation of vimentin, a marker for epithelial-to-mesenchymal transition, is linked to changes in transforming growth factor (TGF)- signaling, affecting cell differentiation and impairing regenerative processes in the bladder

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FIGURE 6 8 Tissue biomarkers of renal toxicity Several biomarkers were elevated in the kidney after vitamin E supplementation in rodents