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Although we failed to detect robust SARS-CoV-2 replication within human monocytes by using this method ( Supplementary Figure 4 ), SARS-CoV-2 exposure to monocytes was sufficient to induce IL-1 secretion at MOI of 1, which was not seen in cultures incubated with HI-CoV-2 at the same MOI or with SARS-CoV-2 media only ( Figure 6A )