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doi: 10.1016/S0140-6736(22)01692-0

Lack of Host SPARC Enhances Vascular Function and Tumor Spread in an Orthotopic Murine Model of Pancreatic Carcinoma

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Beyond its senomorphic effects, exercise also exhibits senolytic activity by promoting autophagic clearance of senescent cells through TFEB activation and increased caspase-3-dependent apoptosis ( 4.4 Exercise enhances mitochondrial function and autophagy systems, restoring cellular quality control Mitochondrial dysfunction and autophagy impairment are major contributors to ferroptosis vulnerability in the aging brain (Wang et al., 2022b