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Statements Author contributions NG, DW, and PA drafted the manuscript and BP, NS, KS, DW, and PA helped in literature search and edited the manuscript

While effective in raising HGH, injecting the hormone itself can suppress the bodys natural production and lead to side effects such as swelling, joint pain, and, in some cases, increased risk of diabetes or certain cancers

Most users find eating large meals physically uncomfortable and naturally gravitate toward smaller, more frequent meals

The theory holds that high lactic acid buildup makes IGF-1 receptors more receptive, so injecting into muscles about to be trained maximizes local effects