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NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives immune evasion in urothelial carcinoma by elevating PD-L1 N-glycosylation

Coadministration with anti-OX40 antibodies further amplified T-cell responses and enhanced tumor regression, underscoring the potential of Mann-NCs as a self-adjuvanted immunomodulatory nanoplatform that bridges PRR-mediated innate sensing with adaptive antitumor immunity