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Each growth factor and receptor can activate a distinct and overlapping array of signaling pathways in selective cell populations leading to modulation of neurotransmission and synaptic plasticity

133,134,135 Researchers found that GCN5 and PCAF acetylate Rae-1 at K80 and K87 to enhance its stability and protect Rae-1 from shedding to activate the immune surveillance of NK cells and CD8 + T cells