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Why antihistamines fall short Traditional H1 antihistamines (cetirizine, loratadine, fexofenadine) block histamine receptors on target tissues

doi: 10.1016/s0014-5793(97)00483-3

Although PCBP depletion leads to loss of c-aconitase activity, it does not appear to lead to a reciprocal increase in IRE-binding activity, suggesting that PCBP depletion does not result in the complete disassembly of the FeS cluster in IRP1