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In addition to glutamine, upregulation of serine/glycine metabolism closely connected with folate metabolism is relevant to high proliferation of tumor cells and poor prognosis of patients (50)

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However, concern related to baseline liver test abnormalities from underlying nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C and risk of hepatotoxicity especially with drugs such as statins and thiazolidinediones (rosiglitazone and pioglitazone) did not really pan out and currently liver safety iof these agents in patients with underlying chronic liver disease is much less of an issue [4650]