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Future efforts must prioritize multi-center trials for safety/PK profiling, biodegradable polymers with tunable degradation, and multi-omics biomarkers for personalized therapy

Immunofluorescence labeling of HSD3B in rat testes and Leydig cells Paraformaldehyde (PFA, 4%)-fixed testis sections or isolated Leydig cells (LCs) were subjected to immunofluorescence staining of 3-hydroxysteroid dehydrogenase (HSD3B)

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Interleukin (IL)-1b, a pro-inflammatory cytokine, was the first cytokine to be identified as enhancing HPA axis activity during an immunological response ( Natural coumarin anti-oxidant 4-methylesculetin (4-MESC) has anti-inflammatory effects on intestinal inflammation, whose pathogenesis and oxidative stress are both major contributors to it (Tanimoto et al., 2020)