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Release of danger/damage-associated molecular patterns (DAMPs), intracellular nucleotides or proteins that become highly immunogenic when liberated into extracellular space, could also occur in primary afferent injury

Science 327 , 331334 (2010)

UA constitutes from xanthine and hypoxanthine and is catalyzed by the mammalian enzyme xanthine oxidase (XO), primarily a dehydrogenase and oxidase enzyme (Fig