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Initially studied for its role in promoting gut health, researchers discovered its extensive healing benefits beyond the gastrointestinal system

Acknowledgements This work was supported by the Joint project of Chongqing Municipal Science and Technology Bureau and Chongqing Health Commission (2023CCXM003), the Natural Science Foundation Project of China (82371526), the Natural Science Foundation of Chongqing (CSTB2024NSCQ-QCXMX0033 and CSTB2024NSCQ-MSX1027), the Young Elite Scientists Sponsorship Program by CAST (2021QNRC001), and the Chongqing Medical Science and Technology Innovation Four Centers Construction Project - Chongqing Clinical Evaluation and Research Center for Cardiovascular and Cerebrovascular Drug and Devices (Materials) Project

Furthermore, epigenetic age acceleration (EAA), an epigenetic biomarker of aging, has been linked to indoor air pollution from coal combustion and associated pulmonary arterial hypertension, particularly 5-methylcytosine, which correlates with the mortality biomarker Grim Age EAA [158]

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