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Crucially, key regulatory signaling pathways that normally bolster antioxidant defenses are also disrupted or insufficiently activated to cope with the overwhelming stress

Simmons, K, Thomas, J, Ludford, K, Willis, JA, Serpas Higbie, V, Raghav, KS, Johnson, B, Dasari, NV, Kee, BK, Parseghian, C, Lee, MS, Le, PH, Morelli, MP, Shen, JY, Bent, AH, Vilar Sanchez, E, Wolff, RA, Kopetz, S , Overman, MJ, Morris, VK

Humanin also modulates the activities of caspases, key mediators of cell death pathways, thereby promoting cell survival in stressful conditions (Nakagawa et al., 2002)

However, these findings were based on surrogate physiological markers and do not establish broader claims of systemic metabolic enhancement or clinical benefit (95)