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Valcheva R, Koleva P, Martnez I, Walter J, Gnzle MG, Dieleman LA

[Abstract] Immunoblot with anti-NCOR2, anti-ACACA, anti-FASN, anti-CAD, and anti--Tubulin antibodies of protein precipitated by streptavidin beads from MDA-MB-231 cell lysates in the presence of B-Emodin or Biotin (10 M) for 5 h at 4 with rotation

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Within this pathological network, mtROS and NLRP3 inflammasome activation form a critical molecular hub: mitochondrial dysfunction induces complexes I and III of the electron transport chain to generate large amounts of mtROS, which triggers NLRP3 inflammasome activation through pathways such as promoting the binding of TXNIP to NLRP3, releasing oxidized mitochondrial DNA (ox-mtDNA) as a co-activator, and modulating mitochondrial membrane potential