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In animal experiments, increases in VEGF were observed at both 2 h and 1 month following TBI, indicating impaired vascularity in both the short and long term (120, 121)

Summary Keywords ferroptosis, angiogenesis, metabolic reprogramming, extracellular vesicles, oxidative stress, tumor microenvironment Citation Tatode A, Chaudhary AA, Qutub M, Trivedi R, Umekar M, Ali MAM and Premchandani T (2025) Dissecting the opposing regulatory functions of endogenous nitric oxide production in colorectal cancer initiation, adaptive immune response alterations, and ferroptosis execution