foxo4 dri senolytic peptide mechanism FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway Molecular modelling of the FOXO4-TP53

Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells ScienceDirect The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. FOXO4 DRI 10mg Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv

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