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This is in response to the free radical increase, and is a means to mitigate stress and maintain a balance between oxidants and antioxidants in tissues

Continuous, uninterrupted dosing is avoided because kisspeptin causes desensitization the LH response fades over time when the receptor is overstimulated

Caregaro L, Alberino F, Amodio P, Merkel C, Angeli P, Plebani M, Bolognesi M, Gatta A: Nutritional and prognostic significance of insulin-like growth factor 1 in patients with liver cirrhosis

Realistic timeline expectations: Patients who expect visible muscle changes within 2 to 3 weeks are typically disappointed