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These drugs or their metabolites covalently bind to proteins in the body to form drug/metabolite-protein adducts that can be processed by antigen-presenting cells as semi-antigens and then recognized by T cells to induce immune responses that may have a genetic or even metabolic basis, with dendritic cells acting as antigen-presenting cells (APCs) bridging the activation of innate and adaptive immunity [3]

Furthermore, inspired by our recent discovery that oxirane warheads, when attached to KRAS G12D -targeting ligands, could simultaneously covalently modify KRAS G12C and KRAS G12D 53 , we also included this warhead in our study