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Notably, citrulline supplementation restores fibroblast activation under arginine-deprived conditions, whereas ornithine and glutamine provide essential precursors for polyamine biosynthesis in fibroblasts [50]

Moreover, devimistat effectively inhibited the activity of PDH and -KGDH, restricted TCA cycle flux, and impeded the in vitro and in vivo growth of GC cells expressing either WT DLD or the hyperacetylation-mimicking DLD K430Q mutant, demonstrating its broad applicability (Supplementary Fig

New York: Humana Press

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