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[109] China [edit] The Chinese patent was scheduled to expire in 2026, but a court ruled in 2022 that all patents on semaglutide were invalid "for reasons related to experimental data availability"

Epigenetic modifications refer to chemical alterations, such as DNA methylation and histone modifications, that regulate gene expression without changing the underlying DNA sequence [168]

JMIR Diabetes 7 , e23243 (2022)

A reversal in the pesticide-induced increase in oxidative stress was also seen in the CYP + BM group, suggesting a reduction in CYP-induced thyroid toxicity