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Retatrutide handles the heavy lifting on appetite and metabolism, while AOD-9604 fills a gap that no incretin-based peptide can address: direct, receptor-level stimulation of fat breakdown

To test the possible increase in potency of the two drugs when given simultaneously, we injected a total volume of 4 ml of combined doses of L838,417 and CLP257 in a fixed dose ratio of \([{\mathrm{L 838,417]/[{\mathrm{CLP 257]\) = 1:55, given the relative EC50s of the two drugs calculated from the respective dose response curves with a priori assumption on the collapse at high doses of L838,417 (Fig

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