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This mechanism is implicated in diseases such as rheumatoid arthritis (RA), where oxidative modifications of proteins in the synovial fluid contribute to the autoimmune response [127, 128]

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Compared to HGPS, the onset of Werner syndrome is slightly slower, in which the pathology accompanies with Werner syndrome resembles a premature aging

Curr Biol 22:R997R999 Gil-Amado JA, Gomez-Jimenez MC (2012) Regulation of polyamine metabolism and biosynthetic gene expression during olive mature-fruit abscission