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The bacteriostatic water used for reconstitution provides antimicrobial protection but does not prevent peptide bond hydrolysis at elevated temperatures

Abulikemu A, Zhao X, Xu H, Li Y, Ma R, Yao Q, et al

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A reduction in expression of mR A administered as part of a repeat-dose regimen, wherein the level of protein translated from the administered R A is reduced by more than 40% in comparison to another dose within the repeat-dose regimen is referred to herein as "repeat-dose resistance." Properties of the Pharmaceutical Compositions [0001790] The pharmaceutical compositions described herein can be characterized by one or more of the following properties: Bioavailability [0001791] The polynucleotides or compositions when formulated into a composition with a delivery agent as described herein, can exhibit an increase in bioavailability as compared to a composition lacking a delivery agent as described herein