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Prospective cohort studies have shown that long-term elevated plasma TMAO levels significantly increase the risk of cardiovascular disease

Furthermore, HUC-MSC-exosome therapy reduces inflammatory response through decreasing F4/80 + and CD11c + macrophages and the levels of tumor necrosis factor-alpha (TNF-) and Interleukins-6 (IL-6) (179)

However, OCTN1 and OCTN2 both have narrower substrate specificity compared to polyspecific OCTs and OATs, and uptake assays performed with a large panel of drugs suggest that OCTN2 is not a general drug transporter 3,12,17,18

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