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GHK-Cu's natural occurrence in human plasma suggests better tolerance for extended therapy, though both appear safe when used appropriately

10.1080/10408444.2020.1838441 117 IranshahyM.JavadiB

Semaglutide primarily targets GLP-1 alone, while Tirzepatide combines GLP-1 and GIP receptor activity, giving it a broader incretin signalling profile