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In the TMLHE gene knockout mouse model, the carnitine biosynthetic pathway is inhibited due to the loss of TMLD activity in the liver, affecting the availability of carnitine in the heart, significantly reducing the rate of synthesis of LCACs, and contributing to the protection of mitochondrial function after myocardial IRI [215]

[DOI] [PubMed] [Google Scholar] 74.Lauderdale K.J., Malone C.L., Boles B.R., Morcuende J., Horswill A.R

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Lactobacillus reuteri can increase the content of C16-carnitine in the intestine, thereby effectively activating the Nrf2/HO-1 signaling pathway to resist hepatic IRI [238]