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202 Management of these mood disorders involves psychological interventions such as cognitive behavioral therapy (CBT) and pharmacotherapy with antidepressants, considering their metabolic effects

These commenters questioned why CMS believes the estimated allowed amount is insufficient to provide context to the payer-specific negotiated charge when it is based on a percentage or algorithm and why the median allowed amount is more useful to consumers of the MRF

This should only be used if the patient has been confirmed to have had inadequate responses to other forms of treatment

While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments