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Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes

TBI mice treated with the amino acid solution for 6 days improved intestinal epithelial barrier function in the ileal mucosa by increasing expression of barrier-forming claudins and removing pore-forming claudin-2 from epithelia TJs

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It can also be achieved by the deamination of glutamate when glutamate or histidine is supplied as the carbon source (Lemire et al., 2010, 2017)