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In Study 2, hydroxocobalamin infusion was associated with moderate hemodynamic effects, including an increase in systemic vascular resistance, an increase in blood pressure, and a decrease in cardiac output

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For collagen-specific support, GHK-Cu can be added at systemic doses via subcutaneous administration or applied topically over affected areas

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Efficacy, side effects, dosing, and how

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More specialized markers such as methylmalonic acid or homocysteine, which can clarify borderline cases, also take weeks to shift

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