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Indeed, by 14 weeks postpartum, total serum B12 concentrations are no longer low (Allen et al., 2018)

Carbon monoxide Carbon monoxide is a potent vasodilator and promotes NO release.59 Endogenously, the production of CO results from the breakdown of senescent erythrocytes through the heme oxidase pathway (a process known as iron scavenging).60 In vitro, not only does V-B12 bind CO, but reduced V-B12 also catalyzes an oxidation of CO to carbon dioxide using ascorbate as a cofactor.7,8 Ascorbic acid can rapidly reduce/supply electrons to V-B12 to generate the reduced or Co 2+ state and super-reduced or Co 1+ forms

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76 Human hepatocyte models are a next logical step, and thus more investigations need to be carried out before either serotonin or SFN can be realistically considered on the therapeutic level