glutathione synthetase deficiency wiki Oxidative stress and GPX2 control

Medication Interactions: Certain medications can affect heat tolerance

they create what researchers refer to as a massive immunological "energy sink." Because the immune cells (particularly T-cells and memory lymphocytes) are trapped in a state of severe oxidative stress, they are forced to consume excessive amounts of the host's energy just to survive the ongoing cellular damage and attempt repairs

This means the part of the brain that is responsible for memory, learning, and emotion, loses its function and more beta-amyloid plaques form (Blzquez, Velzquez, Hurtado-Carneiro, & Ruiz-Albusac, 2014)

doi: 10.1002/mco2.292 3 XuHWuMMaXHuangWXuY