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Nature, 543(7643), 5159

Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice

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FIGURE 3 One potential minor drawback of exogenous cytoplasmic PC expression is the activation of another metabolically futile cycle, with PC functioning together with phosphoenolpyruvate carboxykinase 1 (PCK1) and pyruvate kinase (PKM) to futilely hydrolyze GTP to GDP (Figure 3A), which could inhibit GTP-dependent processes such as endocytosis and autophagy (Santana et al., 2025)